4% ente ea Gentamyclin sulphate
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Pontsho
Ponahalo:Sehlahisoa sena ha se na 'mala ho ea ho mosehla kapa mosehla o tala o hlakileng mokelikeli.
Ketso ea Pharmacological:PharmacodynamicGentamycinke lithibela-mafu tsa aminoglycoside tse nang le phello e thibelang likokoana-hloko ho mefuta e fapaneng ea libaktheria tsa gram-negative (joaloka Escherichia coli, Klebsiella, Proteus, Pseudomonas aeruginosa, Pasteurella, Salmonella, joalo-joalo) le Staphylococcus aureus (ho akarelletsa le β-lacingstrains-pro).Boholo ba cocci (Streptococcus pyogenes, pneumococcus, Streptococcus faecalis, joalo-joalo), libaktheria tsa anaerobic (Bacteroides kapa Clostridium), lefuba la Mycobacterium, Rickettsia le li-fungus li hanyetsa sehlahisoa sena.
Pharmacokinetics:Ho monyela ka potlako le ka botlalo ka mor'a ente ea intramuscular.Likhakanyo tse phahameng li fihlelleha nakong ea hora e 0.5 ho isa ho e 1.Bioavailability e feta 90% bakeng sa ente ea subcutaneous kapa intramuscular.Haholo-holo e ntšoa ke glomerular filtration mme e nka 40% ho isa ho 80% ea lethal dose le fanoeng.Ho felisoa ha halofo ea bophelo ka mor'a ente ea intramuscular ke lihora tse 1.8 ho isa ho tse 3.3 ho lipere, lihora tse 2,2 ho isa ho tse 2.7 ho manamane, lihora tse 0,5 ho isa ho tse 1.5 ho lintja le likatse, hora e le 'ngoe ho likhomo le likolobe, lihora tse 1 ho isa ho tse 2 ho mebutlanyana, le 2.3 ho isa ho 3.2 lihora tse ngata ka linku, linare, likhomo le lipōli tsa lebese.
Tšebelisano ea lithethefatsi:
(1) Motsoako oa Gentamycin le tetracycline le erythromycin e ka ba le phello e hanyetsanang.
(2) Hammoho le cephalosporins, dextran, diuretics tse matla (tse kang furosemide, joalo-joalo), le erythromycin, ototoxicity ea sehlahisoa sena e ka ntlafatsoa.
(3) Li-relaxation tsa mesifa ea masapo (tse kang succinylcholine chloride, joalo-joalo) kapa lithethefatsi tse nang le phello ena li ka ntlafatsa phello ea ho thibela neuromuscular ea HUMIRA.
Ts'ebetso le ts'ebeliso
Likokoana-hloko tsa Aminoglycoside.Bakeng sa tšoaetso ea baktheria ea Gram-negative le e ntle.
Tekanyo le tsamaiso
(1) Ototoxicity.Hangata e baka tšenyo ea li-vestibular tsebeng, e ka mpefalang ka ho bokella lithethefatsi tse tsamaisoang ka mokhoa o tsoelang pele ka mokhoa o itšetlehileng ka lethal dose.
(2) Ka linako tse ling ho kula.Likatse li na le kutloelo-bohloko, kamehla li ka baka ho nyekeloa ke pelo, ho hlatsa, salivation le ataxia.
(3) Litekanyetso tse phahameng li ka baka thibelo ea neuromuscular conduction blockade.Mafu a kotsi a atisa ho etsahala ka mor'a anesthesia e akaretsang bakeng sa mekhoa ea ho buoa lintja le likatse, ho kopantsoe le penicillin ho thibela tšoaetso.
(4) E ka baka nephrotoxicity e ka fetoloang.
Mehato ya tlhokomelo
(1) Gentamycin e ka sebelisoa hammoho le lithibela-mafu tsa β-lactam ho alafa tšoaetso e matla, empa ha e lumellane ha e tsoakoa ka in vitro.
(2) Hammoho le penicillin, sehlahisoa sena se na le phello ea synergistic ho streptococci.
(3) E na le khatello ea maikutlo 'me ha ea lokela ho kenngoa ka methapo.
(4) Khahlano e ka 'na ea etsahala hammoho le tetracycline le erythromycin.
(5) Ho kopana le cephalosporins ho ka ntlafatsa nephrotoxicity.
Nako ea ho hula
Kolobe, khomo le nku ka matsatsi a 40.
Polokelo
Koaletsoe le ho bolokoa sebakeng se pholileng se lefifi.
Hebei Veyong Pharmaceutical Co., Ltd, e thehiloe ka 2002, e Shijiazhuang City, Profinseng ea Hebei, China, haufi le Motse-moholo Beijing.Ke khoebo e kholo ea meriana ea liphoofolo e netefalitsoeng ke GMP, e nang le R&D, tlhahiso le thekiso ea li-API tsa bongaka ba liphoofolo, litokisetso, lijo tse tsoakiloeng le li-additives.E le Setsi sa Botekgeniki sa Provinsi, Veyong e thehile sistimi e nchafalitsoeng ea R&D bakeng sa moriana o mocha oa bongaka ba liphoofolo, 'me ke khoebo e tsebahalang naheng ka bophara ea theknoloji e thehiloeng ho bongaka ba liphoofolo, ho na le litsebi tse 65 tsa tekheniki.Veyong e na le metheo e 'meli ea tlhahiso: Shijiazhuang le Ordos, eo setsi sa Shijiazhuang se koahelang sebaka sa 78,706 m2, se nang le lihlahisoa tsa 13 tsa API tse kenyeletsang Ivermectin, Eprinomectin, Tiamulin Fumarate, Oxytetracycline hydrochloride ects, le 11, lihlahisoa tsa tlhahiso ea oral powder , premix, bolus, chefo e bolaeang likokoanyana le sebolaea likokoana-hloko, joalo-joalo.Veyong e fana ka li-API, litokisetso tse fetang 100 tsa li-label, le tšebeletso ea OEM & ODM.
Veyong e nka bohlokoa bo boholo taolong ea sistimi ea EHS(Tikoloho, Bophelo bo Botle le Polokeho), mme e fumane litifikeiti tsa ISO14001 le OHSAS18001.Veyong e thathamisitsoe ho likhoebo tse ntseng li tsoela pele tsa indasteri Profinseng ea Hebei mme e ka netefatsa phepelo e tsoelang pele ea lihlahisoa.
Veyong e thehile sistimi e felletseng ea taolo ea boleng, ea fumana setifikeiti sa ISO9001, setifikeiti sa China GMP, setifikeiti sa Australia sa APVMA GMP, setifikeiti sa Ethiopia GMP, setifikeiti sa Ivermectin CEP, mme sa feta tlhahlobo ea US FDA.Veyong e na le sehlopha sa profeshenale sa ngoliso, thekiso le tšebeletso ea tekheniki, k'hamphani ea rona e fumane ts'epo le ts'ehetso ho tsoa ho bareki ba bangata ka boleng bo botle ba sehlahisoa, tšebeletso ea boleng bo holimo ea pele ho thekiso le ka mor'a thekiso, taolo e tebileng le ea mahlale.Veyong e entse tšebelisano ea nako e telele le likhoebo tse ngata tse tsebahalang lefatšeng ka bophara tsa meriana ea liphoofolo tse nang le lihlahisoa tse romelloang Europe, Amerika Boroa, Bochabela bo Hare, Afrika, Asia, joalo-joalo linaha le libaka tse fetang 60.
