Tildipirosin
.png)
.png)
.png)
.png)
Tildipirosin
Tildipirosin ke mofuta o mocha oa semi-synthetic 16-membered ring macrolide lithibela-mafu bakeng sa liphoofolo, e leng e tsoang ho tylosin.
Ketso ea Pharmacological
Tšusumetso ea antibacterial ea Tildidirosin e tšoana le ea tylosin, 'me e na le phello e matla ea ho thibela likokoana-hloko ho libaktheria tsa Gram-positive le tse ling tsa Gram-negative.Mokhoa oa antibacterial oa Tildidirosin o tšoana le oa macrolides.E ka kopana le subunit ea 50S ea ribosome ea libaktheria tse hlokolosi ho thibela motsoako oa liketane tsa peptide tsa riboprotein, ka tsela eo e ama tlhahiso ea liprotheine tsa baktheria.Ho sebelisana ha likarolo tse peli tsa piperidine tse ikhethang ho Tildidirosin ho khetholla mokhoa oa ts'ebetso ea moriana ona ho tloha tylosin le tilmicosin, moo 20-piperidine e lebisitsoeng ho lumen ho kena-kenana le ho hōla ha li-peptide tse sa tsoa tsoaloa.
Hobane tediroxine e na le lihlopha tse 3 tsa mantlha tsa amino, e ka theha mefuta e fapaneng ea tefiso tlasa maemo a fapaneng a pH.Chelete ea tefiso ke ntlha ea bohlokoa ea ho senya ho qhibiliha ha lipids tsa baktheria le ho phunyeletsa lera le ka ntle la libaktheria tsa Gram-negative, kahoo ts'ebetso ea bacteriostatic ea Tildidirosin in vitro e ameha haholo ke pH.Tlas'a maemo a acidic, sehlopha sa amino se na le protonated, e leng se bakang ho fokotseha ha tšebetso ea antibacterial ea tediroxine, ha tlas'a maemo a alkaline, e na le ts'ebetso e matla ea antibacterial.
Macrolides e thibela secretion ea proinflammatory cytokines, phospholipase le tokollo ea leukotriene, 'me e na le litlamorao tse khahlanong le ho ruruha ho macrophages le neutrophils.Tediroxine e fokotsa bakena-lipakeng ba ho ruruha ba hlahisoang nakong ea likarabo tse itseng tsa ho ruruha kapa khatello ea maikutlo.
Antibacterial spectrum
Tildipirosin e sebetsa khahlano le libaktheria tsa pathogenic tse bakang mafu a ho hema likolobe le likhomo (tse kang Pasteurella multocida, Actinobacillus pleuropneumoniae, Bordetella bronchiseptica, Haemophilus parasuis, Mannheim spp. joalo-joalo) ts'ebetso ea antibacterial ea tilmicosin e ne e phahame ka makhetlo a 2-32 ho feta ea tilmicosin ka makhetlo a 2-32 ho feta ea tilmicosin. , 'me mosebetsi oa antibacterial khahlanong le intestinal Escherichia coli o ne o le betere ho feta tylosin le tilmicosin.E boetse e nahanela mefuta e meng ea mycoplasma, spirochetes, brucella, joalo-joalo Liphuputso li bontšitse hore tediroxine e na le phello e matla ea bacteriostatic ho Haemophilus parasuis le Bordetella bronchiseptica ho feta florfenicol, empa phello e fokolang ea bacteriostatic ho Actinobacillus pleuropneumoniae le Pasteurella multocida.Tildipirosin e thibela likokoana-hloko ho libaktheria tse ling (joaloka Haemophilus parasuis le Actinobacillus pleuropneumoniae), athe haholo-holo ke bacteriostatic ho libaktheria tse ling (joaloka Pasteurella multocida).Bakeng sa libaktheria tsa mala, ka ho fokotseha ha pH (ho tloha ho 7.3 ho ea ho 6.7), MIC ea Tildidirosin e ile ea eketseha, ka mohlala, MIC ea Tildipirosin khahlanong le Salmonella Enteritidis le Escherichia coli e ka eketseha ho tloha 2 ~ 8ug / m ho 64 ~ 256ug / mL. .Ka hona, phello ea liphetoho tsa pH ho vivo e lokela ho nahanoa ha ho etsoa tlhahlobo ea in vivo antibacterial ea Tildidirosin.Ho phaella moo, MIC ea Tildidirosin khahlanong le mefuta e tloaelehileng ea Pasteurella multocida e ne e le 0.5ug / mL ka serum, e neng e le ka makhetlo a 0.25 ka tlase ho feta in vitro, e ka 'nang ea amana le phello ea serum.
Enterococcus-Streptococcus ka dikgomong tsa lebese e hanyetsana haholo le tediroxine.Tildipirosin ha e utloe ho Pasteurella multocida le Mannheimia haemolyticus e tsamaisang liphatsa tsa lefutso tse fetotsoeng.Ka mokhoa o ts'oanang, mefuta ea liphatsa tsa lefutso tsa M. bovis e hanyetsana le lithibela-mafu tsa macrolide tse kenyelletsang Tildidirosin.Mefuta e meng ea Haemophilus parasuis le eona e fumanoe e hanana le tediroxine ka tlhaho.Mycoplasma bovis e ka khona ho hanyetsa Tildidirosin ka potlako, empa ka lebaka la kholo e liehang ea Mycoplasma, tlhahlobo ea in vitro ea ho ba le ts'oaetso ea lithethefatsi e ka liehisa kalafo.Liphuputso li bontšitse hore domain II (nucleotide 748) le domain V (Ho fetoha ha li-nucleotides 2059 le 2060) ho amahanngoa le ho eketseha ha khanyetso ho macrolides.Ka hona, ts'oaetso ea M. bovis ho lithethefatsi tsa macrolide e ka fumanoa ka potlako ka tlhahlobo ea limolek'hule ea phetoho ena.
Litaba
≥ 98%
Tlhaloso
Tekanyetso ea k'hamphani
Hebei Veyong Pharmaceutical Co., Ltd, e thehiloe ka 2002, e Shijiazhuang City, Profinseng ea Hebei, China, haufi le Motse-moholo Beijing.Ke khoebo e kholo ea meriana ea liphoofolo e netefalitsoeng ke GMP, e nang le R&D, tlhahiso le thekiso ea li-API tsa bongaka ba liphoofolo, litokisetso, lijo tse tsoakiloeng le li-additives.E le Setsi sa Botekgeniki sa Provinsi, Veyong e thehile sistimi e nchafalitsoeng ea R&D bakeng sa moriana o mocha oa bongaka ba liphoofolo, 'me ke khoebo e tsebahalang naheng ka bophara ea theknoloji e thehiloeng ho bongaka ba liphoofolo, ho na le litsebi tse 65 tsa tekheniki.Veyong e na le metheo e 'meli ea tlhahiso: Shijiazhuang le Ordos, eo setsi sa Shijiazhuang se koahelang sebaka sa 78,706 m2, se nang le lihlahisoa tsa 13 tsa API tse kenyeletsang Ivermectin, Eprinomectin, Tiamulin Fumarate, Oxytetracycline hydrochloride ects, le 11, lihlahisoa tsa tlhahiso ea oral powder , premix, bolus, chefo e bolaeang likokoanyana le sebolaea likokoana-hloko, joalo-joalo.Veyong e fana ka li-API, litokisetso tse fetang 100 tsa li-label, le tšebeletso ea OEM & ODM.
Veyong e nka bohlokoa bo boholo taolong ea sistimi ea EHS(Tikoloho, Bophelo bo Botle le Polokeho), mme e fumane litifikeiti tsa ISO14001 le OHSAS18001.Veyong e thathamisitsoe ho likhoebo tse ntseng li tsoela pele tsa indasteri Profinseng ea Hebei mme e ka netefatsa phepelo e tsoelang pele ea lihlahisoa.
Veyong e thehile sistimi e felletseng ea taolo ea boleng, ea fumana setifikeiti sa ISO9001, setifikeiti sa China GMP, setifikeiti sa Australia sa APVMA GMP, setifikeiti sa Ethiopia GMP, setifikeiti sa Ivermectin CEP, mme sa feta tlhahlobo ea US FDA.Veyong e na le sehlopha sa profeshenale sa ngoliso, thekiso le tšebeletso ea tekheniki, k'hamphani ea rona e fumane ts'epo le ts'ehetso ho tsoa ho bareki ba bangata ka boleng bo botle ba sehlahisoa, tšebeletso ea boleng bo holimo ea pele ho thekiso le ka mor'a thekiso, taolo e tebileng le ea mahlale.Veyong e entse tšebelisano ea nako e telele le likhoebo tse ngata tse tsebahalang lefatšeng ka bophara tsa meriana ea liphoofolo tse nang le lihlahisoa tse romelloang Europe, Amerika Boroa, Bochabela bo Hare, Afrika, Asia, joalo-joalo linaha le libaka tse fetang 60.
